Gary W Cline Selected Research

Malonyl Coenzyme A (Malonyl CoA)

3/2006	Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.
3/2004	Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance.

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Gary W Cline Research Topics

Disease

55	Insulin Resistance 01/2023 - 03/2002
21	Type 2 Diabetes Mellitus (MODY) 01/2023 - 03/2002
13	Non-alcoholic Fatty Liver Disease 01/2021 - 03/2006
12	Hyperglycemia 01/2020 - 10/2002
12	Obesity 02/2019 - 04/2003
9	Body Weight (Weight, Body) 01/2022 - 05/2007
6	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 11/2020 - 06/2012
5	Hypertriglyceridemia 10/2019 - 05/2002
4	Glucose Intolerance 12/2020 - 06/2005
4	Fatty Liver 10/2017 - 07/2005
3	Hyperinsulinism (Hyperinsulinemia) 01/2020 - 12/2004
3	Hyperphagia (Overeating) 02/2019 - 04/2010
3	Hypoglycemia (Reactive Hypoglycemia) 01/2019 - 04/2007
3	Inflammation (Inflammations) 01/2019 - 05/2007
3	Weight Gain 07/2016 - 01/2013
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2016 - 07/2007
2	Weight Loss (Weight Reduction) 01/2020 - 05/2012
2	Overweight 01/2020 - 04/2003
2	Pinta 11/2019 - 10/2017
2	Starvation 11/2019 - 11/2018
2	Diabetic Ketoacidosis (Ketoacidosis, Diabetic) 02/2017 - 07/2014
2	Hyperlipidemias (Hyperlipidemia) 01/2015 - 05/2007
2	Insulinoma 12/2013 - 09/2011
1	Adenocarcinoma of Lung 12/2019
1	Necrosis 01/2019

Drug/Important Bio-Agent (IBA)

37	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 05/2002
27	LipidsIBA 01/2023 - 03/2002
25	Insulin (Novolin)FDA Link 01/2021 - 03/2002
20	Triglycerides (Triacylglycerol)IBA 01/2023 - 03/2002
13	Fatty Acids (Saturated Fatty Acids)IBA 12/2018 - 03/2002
11	DiglyceridesIBA 10/2020 - 07/2005
8	Acetyl Coenzyme A (Acetyl-CoA)IBA 11/2018 - 03/2006
8	Acyl Coenzyme A (Acyl CoA)IBA 01/2018 - 04/2003
5	Protein Kinase C-epsilonIBA 01/2022 - 08/2007
5	LeptinIBA 01/2020 - 05/2002
5	GlycogenIBA 01/2020 - 10/2002
5	Liver GlycogenIBA 01/2020 - 12/2004
5	EnzymesIBA 12/2018 - 03/2004
4	Acetates (Acetic Acid Esters)FDA Link 01/2023 - 07/2014
4	CarbohydratesIBA 01/2021 - 07/2007
4	Coenzyme A (CoA)IBA 11/2018 - 03/2004
4	CytokinesIBA 01/2017 - 09/2005
4	Antisense OligonucleotidesIBA 05/2013 - 03/2006
3	Protein Kinases (Protein Kinase)IBA 01/2023 - 05/2007
3	GhrelinIBA 01/2023 - 01/2016
3	Transcription Factors (Transcription Factor)IBA 01/2021 - 04/2007
3	Nonesterified Fatty Acids (NEFA)IBA 01/2020 - 12/2004
3	Lactic Acid (Lactate)FDA LinkGeneric 01/2020 - 09/2014
3	Amino Acids FDA Link 12/2019 - 04/2007
3	Alanine (L-Alanine)FDA Link 11/2019 - 04/2007
3	FructoseIBA 10/2019 - 01/2013
3	Interleukin-6 (Interleukin 6)IBA 01/2019 - 09/2005
3	Tyrosine (L-Tyrosine)FDA Link 01/2019 - 09/2005
3	Pyruvic Acid (Pyruvate)IBA 10/2017 - 04/2007
3	Phosphates (Orthophosphate)IBA 10/2016 - 07/2005
3	Glycerol (Glycerine)FDA LinkGeneric 07/2014 - 03/2002
3	AcyltransferasesIBA 06/2010 - 07/2005
2	Proteins (Proteins, Gene)FDA Link 01/2023 - 12/2019
2	Hormones (Hormone)IBA 01/2023 - 07/2014
2	Insulin ReceptorIBA 12/2020 - 09/2005
2	CeramidesIBA 12/2020 - 11/2014
2	naxagolideIBA 11/2020 - 01/2020
2	Glucagon (Glukagon)FDA Link 01/2020 - 12/2004
2	Pyruvate CarboxylaseIBA 11/2019 - 07/2013
2	PhosphoenolpyruvateIBA 01/2019 - 07/2005
2	Acetyl-CoA CarboxylaseIBA 12/2018 - 10/2007
2	dihydrotetrabenazineIBA 12/2018 - 10/2018
2	Sucrose (Saccharose)IBA 12/2018 - 07/2005
2	Adenosine Triphosphate (ATP)IBA 01/2018 - 10/2016
2	Metformin (Glucophage)FDA LinkGeneric 01/2018 - 06/2014
2	Insulin Receptor Substrate ProteinsIBA 12/2008 - 12/2002
2	AdiponectinIBA 07/2007 - 11/2005
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2007 - 05/2007
2	Deoxyglucose (2 Deoxy D glucose)IBA 05/2007 - 11/2004
2	PPAR alphaIBA 04/2007 - 09/2005
2	Malonyl Coenzyme A (Malonyl CoA)IBA 03/2006 - 03/2004
2	Phosphatidylinositols (Phosphatidylinositol)IBA 09/2005 - 07/2003
1	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2023
1	Dietary Fiber FDA Link 01/2023
1	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 01/2023
1	Lactulose (Duphalac)FDA LinkGeneric 01/2023
1	Phosphotransferases (Kinase)IBA 12/2020
1	microsomal triglyceride transfer proteinIBA 12/2020
1	O(4)-methylthymidine triphosphateIBA 12/2020
1	Triiodothyronine (Liothyronine)FDA LinkGeneric 01/2020
1	IsotopesIBA 01/2020
1	Dopamine (Intropin)FDA LinkGeneric 01/2020
1	Cyclin B1IBA 12/2019
1	Estradiol (Delestrogen)FDA LinkGeneric 01/2019
1	Essential Amino AcidsIBA 01/2019
1	GlucokinaseIBA 01/2019
1	GlucocorticoidsIBA 01/2019
1	Levodopa (L Dopa)FDA LinkGeneric 01/2019
1	AminesIBA 01/2019
1	Histamine (Histamine Dihydrochloride)FDA Link 01/2019
1	Histidine (L-Histidine)FDA Link 01/2019

Therapy/Procedure

6	Therapeutics 01/2020 - 05/2002
1	Oral Administration 01/2022
1	Bariatric Surgery 01/2021
1	Ketogenic Diet 01/2020